Evaluation of DNA Fragmentation in Human Spermatozoa

This test assesses the correct structuring of chromatin in sperm and calculates the result as a percentage. It serves as a prognostic-diagnostic tool for evaluating the degree of DNA damage (fragmentation) in the genetic material of male gametes. The test can detect varying degrees of genetic abnormalities in sperm, such as excessive DNA fragmentation and immature chromatin. These abnormalities can affect not only a man’s fertilization ability but also the quality of embryo development, implantation, and pregnancy outcomes.

High levels of DNA fragmentation in sperm are associated with infertility, repeated pregnancy loss, and poor outcomes in assisted reproductive techniques such as IVF and ICSI. The test is particularly recommended for men with unexplained infertility, poor embryo development, or recurrent miscarriage.